Aldiwani H, Zaya M, Suppogu N, et al. - Given the prevalence of recurrent hospitalization among females with signs and symptoms of ischemia and no obstructive coronary artery disease, researchers investigated if advances in diagnostic and therapeutic approaches have led to a shift in the rates of angina hospitalization over time. A follow-up of 9.1 years was performed in 551 women registered in the WISE (Women's Ischemia Syndrome Evaluation) study with no obstructive coronary artery disease (CAD). This analysis involved 223 women with nonobstructive CAD (> 20–50% < stenosis) and 328 with no CAD (< 20% stenosis). For a maximum of 9.1 years, near-linear increases in the rates of angina hospitalization were seen in both groups. Univariate predictors of angina hospitalization included hypertension, dyslipidemia, nonobstructive CAD, use of nitrates, statins, and angiotensin-converting enzyme inhibitors. For angina hospitalization, significant adjusted multivariate hazard ratios were reported for use of nitrates 2.58, statins 1.80, and angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers 1.81. Findings revealed that despite medical advancements, angina hospitalization rates continued at a relatively constant rate among all women with no obstructive CAD.