Cook O, et al. - The researchers conducted this trial to compare the pain related to anesthetic solution deposition and the degree of pulpal anesthesia obtained with the combination of prilocaine and lidocaine vs a lidocaine and lidocaine combination when used for inferior alveolar nerve blocks (IANBs). The pulpal anesthetic success for IANBs was not increased with the combination of 4% prilocaine plain plus 2% lidocaine with 1:100,000 epinephrine compared to a combination of 2 cartridges of 2% lidocaine with 1:100,000 epinephrine. Results suggested that pain related to anesthetic solution deposition from the first cartridge of 4% prilocaine plain was notably less than with the first cartridge of 2% lidocaine with 1:100,000 epinephrine.