Wang ET, Diamond MP, Alvero R, et al. - Researchers investigated the value of biochemical or clinical markers of androgenic activity for predicting live birth rate with ovarian stimulation in the unexplained infertility population. They conducted secondary analysis of the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation clinical trial including 900 couples with unexplained infertility. Randomization of women to receive gonadotropin, clomiphene, or letrozole with IUI for four or fewer four treatment cycles, was done. Biochemical (total testosterone, DHEAS, and free androgen index) and clinical markers of androgenic activity (sebum, acne, and hirsutism) were assessed in these women. Outcomes revealed no predictive value of biochemical and clinical measures of androgens for live birth rate after ovarian stimulation treatment.