Margonis GA, et al. - This study aimed to assess the potential clinical advantage of anatomical resection versus nonanatomical resection for colorectal liver metastases, according to KRAS mutational status. Nonanatomical tissue-sparing hepatectomies seemed associated with worse disease-free survival (DFS) in patients with KRAS-mutated tumors. In view of the aggressive nature of KRAS-mutated CRLM, more extensive anatomical hepatectomies were recommended.