Omar M, et al. - Researchers identified the anatomic location and histology of recurrences after successful endoscopic eradication therapy (EET) with the objective of developing a more effective and evidence-based surveillance biopsy protocol. From 2005 to 2015, they performed an analysis of a large multicenter database of 443 patients who had EET and achieved complete eradication of intestinal metaplasia (CE-IM). In the final assessment, 50 patients with BE recurrence were studied. Investigators found that recurrence is identified predominantly in the distal esophagus after EET detected by random biopsy sampling and occurs earlier compared to visible recurrence. Authors, therefore, propose a modified biopsy protocol with targeted sampling of visible lesions followed by random biopsy sampling within 2 cm from the SCJ to optimize the detection of recurrence after EET. Findings revealed that late recurrences (>1 year) were more probable to be noticeable than early (<1 year) recurrences.