Katritsis DG, Pantos I, Zografos T, et al. - Since there exists a controversy regarding the effect of anatomic features of coronary stenoses on the development of future coronary thrombosis, therefore, researchers investigated the anatomic as well as the flow characteristics of left anterior descending (LAD) coronary artery stenoses that predispose to myocardial infarction, by assessing angiograms collected prior to the index event. Most of the culprit lesions resulting in ST-elevation myocardial infarction (STEMI) developed between 20 and 40 mm from the LAD ostium, whereas the most of the stable lesions not related to STEMI were identified in distances > 60 mm. Culprit lesions, in comparison with stable ones, were identified to be significantly more stenosed and significantly longer. Excellent accuracy in predicting the development of a culprit lesion was afforded by a multiple logistic regression model with diameter stenosis, lesion length, distance from the LAD ostium, distance from bifurcation, and lesion symmetry. Overall, experts suggested the likely usefulness of specific anatomic as well as hemodynamic features of LAD stenoses, detected on coronary angiograms, in aiding risk stratification of patients, by enabling the prediction of sites of future myocardial infarction.