Lorenzo-Vizcaya A, et al. - This study was intended to provide a detailed analysis of the causes of death, main characteristics, and trends in the management of the deceased Systemic Lupus Erythematosus (SLE) patients from the lupus clinic at the University College London Hospital (UCLH); during the past four decades. Researchers conducted a non-interventional, retrospective study based on historical real-world data from paper and electronic records of patients followed up at UCLH. They obtained the: causes of death, duration of disease, key laboratory and clinical parameters, and the treatment received. The results from the four decades were compared to ascertain trends in the causes of mortality. In the analysis, 111 SLE patients (15%), died during follow-up. According to the findings, this retrospective review exhibits how epidemiological factors, causes of death, and treatment of SLE patients have changed during the last 40 years in the UCLH cohort.