Wang C, et al. - The toxic effects associated with stereotactic body radiation therapy (SBRT) for ultracentral lung tumors were reported, with a focus on exposure to antiangiogenic agents (AAAs). For lung cancer, SBRT is an effective and generally safe treatment, however, within the central lung zone, SBRT is reported leading to a higher rate of toxic effects. A higher risk of toxic effects is suggested for patients receiving SBRT for tumors abutting the proximal bronchial tree or esophagus, known as “ultracentral” tumors. SBRT toxic effects in other body sites may potentiate in correlation to receipt of AAAs.