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Analysis of the association between kidney injury biomarkers concentration and nephritis in immunoglobulin A vasculitis: A pediatric cohort study

International Journal of Rheumatic Diseases Jul 09, 2020

Dyga K, Machura E, Świętochowska E, et al. - Among patients with immunoglobulin A vasculitis (IgAV), this inquiry was performed to determine the clinical course, selected biochemical parameters as well as levels of renal injury biomarkers such as neutrophil gelatinase‐associated lipocalin (NGAL), kidney injury molecule‐1 (KIM‐1) and liver‐fatty acid binding protein (L‐FABP), to define the markers related to nephritis in the course of the disease (IgAVN). Overall 29 children with IgAV and 34 healthy controls were examined. The serum as well as urine concentrations of NGAL, KIM‐1 and L‐FABP were shown to be significantly higher in children with an acute phase of IgAV vs the control group and markedly lower during follow‐up retesting vs the values collected at inclusion. In this study, experts have established no evident link between the levels of NGAL, KIM‐1 and L‐FABP and nephritis in the course of IgAV in children. In addition, a significant male predominance in patients with nephritis was corroborated.

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