Prucnal CK, et al. - From a pulmonary embolism (PE) response team (PERT) database, researchers assessed adult patients with acute PE for whom the PERT was consulted and were provided anticoagulation (AC) with unfractionated heparin (UFH) according to guideline standard dosing in order to determine the proportion of these patients achieving therapeutic activated partial thromboplastin time (aPTT) values within 48 hours of treatment. Assessment of a total of 505 patients was done; of these, the majority spend most of their first 48 hours outside of the therapeutic range of AC when treated with guideline standard dosing of UFH. No therapeutic PTT level was achieved in over half of the patients within 24 hours of UFH initiation, and there was no patient who had all therapeutic aPTTs.