Tandon N, et al. - Via a comparative analysis of 239 patients who underwent 260 consecutive intracranial evaluations of intractable epilepsy, the contributors intended to perform a comparative analysis of the relative efficacy, procedural morbidity, and epilepsy outcomes resultant to stereoelectroencephalography (SEEG) and subdural electrode (SDE) in similar patient populations and performed by a single surgeon at 1 center. The direct comparison of large matched cohorts undergoing SEEG and SDE implantation revealed distinctly better procedural morbidity favoring SEEG. With SEEG being more versatile and applicable to a range of scenarios, including nonlesional and bilateral cases, than SDE, these modalities intrinsically evaluated somewhat different populations. When patients with pharmacoresistant epilepsy were considered for intracranial evaluations, the crucially favorable adverse effect profile of SEEG could be counted into decision making.