Amirzadegan M, Sadeghi N, Tavalaee M, et al. - This study’s findings demonstrate that in men, low sperm concentration is possibly a sign of impaired meiotic and/or meiotic division during the spermatogenesis process. The results indicated that it is not only correlated with proper chromatin packaging but also with telomere length as a key player in the process of mitosis and meiosis, assisting in chromosomal alignment, pairing, synapsis, and crossing over during spermatogenesis.

• This research sought to evaluate leucocyte and sperm telomere length (LTL&STL), as well as sperm parameters, DNA damage, and protamine deficiency in men with oligozoospermia as compared to fertile men.

• A significant reduction was observed in sperm parameters (concentration, motility, morphology), LTL & STL, and a significant increase in sperm DNA damage and protamine deficiency in oligozoospermic men in comparison with fertile individuals.