Chia PL, Russell P, Asadi K, et al. - Since the of efficacy of agents targeting vascular endothelial growth factor (VEGF) and multi-kinase inhibitors has been recently seen in malignant mesothelioma (MM), researchers examined platelet-derived growth factor (PDGF)-CC, fibroblast growth factor receptor (FGFR)-1, VEGF, and CD31 expression using immunohistochemical staining in this study with 326 patients with MM who were managed surgically. From formalin-fixed, paraffin-embedded tissue samples collected from these patients, tissue microarrays were developed. Regardless of histology, CD31 ≥5 was identified in only 31/302 (10.3%) samples. In 203 /310 (65%) of all samples, PDGF-CC ≥150 was seen. In 127/310 (41%) of all MM, FGFR-≥40 was observed. According to the findings, high CD31 was identified as an independent poor prognostic factor and high PDGF-CC expression was shown to be related to poor survival in MM. It was inferred that abrogating these pathways may have prognostic implications.