Yang F, et al. - In this retrospective study, researchers tested the outcomes of intranasal procedural sedation using a combination of dexmedetomidine and ketamine for diagnostic examination in children, with the main focus on the rate of successful sedation and adverse events. Participants were a total of 17,948 pediatric patients (7,718 females, 10,230 males) in a tertiary hospital in China. Procedural sedation was provided with a combination of 2 μg kg^-1 of dexmedetomidine and 1 mg kg^-1 of ketamine intranasally. Using the Modified Observer Assessment of Alertness/Sedation scale and the Modified Aldrete Score, level of sedation and recovery was evaluated. Findings revealed acceptable effectiveness and low rates of adverse events associated with procedural sedation using a combination of intranasal dexmedetomidine and ketamine.