Sud A, Chattopadhyay S, Thomsen H, et al. - Using the Swedish Family-Cancer Database, researchers analyzed data on over 16 million individuals to determine the familial risk of the various hematological malignancies as well as their possible inter-relationship. Overall 153,115 patients who received a diagnosis of a primary hematological malignancy were identified. In 391,131 first-degree relatives of these patients, standardized incident ratios were calculated to quantify familial relative risks (FRRs). For the same tumor type, increased FRRs were displayed by most of the hematological malignancies. For mixed cellularity Hodgkin lymphoma, lymphoplasmacytic lymphoma and mantle cell lymphoma, the highest FRRs were noted. Also, pleiotropic links were evident, notably an increased familial risk of other B-cell tumors and myeloproliferative neoplasms was found in relation to chronic lymphocytic leukemia. As per the evidence generated in this study, many hematological malignancies had shared etiological factors. For the detection of people at increased risk and for informing future gene discovery initiatives, information was generated in this inquiry.