Analgesic efficacy, safety, and tolerability of a long-acting abuse-deterrent formulation of oxycodone for moderate-to-severe chronic low back pain in subjects successfully switched from immediate-release oxycodone
Journal of Pain Research Oct 05, 2018
Markman J, et al. - Researchers evaluated the safety, tolerability, and analgesic efficacy of oxycodone DETERx extended-release, abuse-deterrent capsules, in patients with chronic low back pain who had successfully transitioned from immediate-release oxycodone. In this post hoc analysis of data from a randomized, double-blind, placebo-controlled, enriched-enrollment phase 3 study, they examined continuous outcomes using a mixed-model repeated-measures approach, binomial outcomes using chi-squared, and time-to-event outcomes using Kaplan–Meier analyses. Findings revealed that oxycodone DETERx had clinically meaningful and statistically significant effect in in this patient population.
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