Rua T, Watson H, Malhotra B, et al. - The present study was undertaken to assess the clinical and cost implications of using CT colonography (CTC) compared with optical colonoscopy (OC) as the initial colonic investigation in patients with low-to-intermediate risk of colorectal cancer (CRC). Researchers performed a non-randomised, prospective single-centre study including a total of 180 individuals to compare the cost implications of two clinical pathways applied in the diagnosis of low-to-intermediate risk of CRC that differ in the initial diagnostic test, either CTC or OC. They compared costs applying generalised linear models and combined with quality-adjusted life years (QALYs, based on the EQ-5D-5L) to calculate cost-effectiveness at 6 months post-recruitment. Access to care and patient satisfaction were considered as secondary outcomes. For patients with low-to-intermediate risk of CRC, the utilisation of CTC as the first-line assessment has the potential to release OC capacity, of pivotal importance for patients more likely to benefit from an invasive diagnostic technique.