Wang Y, et al. - Researchers deliberated that a graded surgically induced, systemic inflammatory response alters cerebrospinal fluid (CSF) levels of morphine, morphine-3-glucuronide (M3G), and morphine-6-glucuronide (M6G) through a temporary reduction in BBB drug efflux transporter function. It has been validated that morphine distribution into the cerebrospinal fluid was not significantly altered in patients undergoing thoracic aortic aneurysm repair. The data illustrtaes that BBB P-glycoprotein (PGP) function may not be affected by the perioperative inflammatory response.