Egnot NS, et al. - This research incorporated the identification of distinct factors derived from circulating inflammatory and coagulation biomarkers along with the analysis of the correlations of these factors with measures of lower extremity subclinical atherosclerosis, with the inclusion of ankle-brachial index (ABI), common and superficial femoral intima-media thickness (IMT), and atherosclerotic plaque presence, burden and characteristics. Through exploratory factor analysis (EFA) of 7 circulating biomarkers of inflammation and coagulation, 2 groupings of biomarkers were detected. These distinct groups exhibited a differential link with markers of lower extremity subclinical atherosclerosis. High inflammatory and coagulation burden served as better markers of more severe lower-extremity disease, which was revealed via low ABI instead of early atherosclerotic lesion development in the femoral artery.