Dhana K, et al. - Researchers conducted an epigenome-wide association study on obesity-related traits. The data was used from 2 prospective, population-based cohort studies: The Rotterdam Study (RS) (2006–2013) and the Atherosclerosis Risk in Communities (ARIC) Study (1990–1992). To evaluate the cross-sectional relationship between genome-wide DNA methylation in leukocytes with body mass index (BMI) and waist circumference (WC) adjusting for sex, age, smoking, leukocyte proportions, array number and position on array, linear mixed-effect models were used. Findings suggested novel associations of methylation at MSI2 and LARS2 with obesity-related traits. Further insight in mechanisms underlying obesity-related traits, which could enable identification of new biomarkers in obesity-related chronic diseases was provided in the findings.