Shin WS, Di J, Cao Q et al. - Since recent research has highlighted synergistic interactions between aggregated amyloid-β (Aβ) and tau proteins in Alzheimer disease (AD), researchers tested the assumption that Aβ potentiates intracellular tau aggregation, and demonstrate that oligomeric Aβ specifically exacerbates proteopathic seeding by tau. According to findings, Aβ's ability to facilitate tau seeding suggests a specific and plausible mechanism by which a deleterious cascade unique to AD is triggered by extracellular Aβ. Such data suggest that consideration should also be given to the Aβ-mediated potentiation of tau uptake into cells when designing Aβ-targeted therapies.