Ishai A, et al. - In Massachusetts General Hospital, Boston, Massachusetts, researchers analyzed 246 individuals to estimate the relation of higher activity of the amygdala (AmygA) (a neural center involved in the response to stress) with elevated visceral adipose tissue (VAT) volumes and also to know if this relationship was mediated by improved bone marrow activity. After adjustment for age and sex, they noticed a significant correlation between AmygA and baseline body mass index, VAT, and VAT/subcutaneous adipose tissue ratio. They recorded 48% of the relationship between AmygA and baseline VAT mediated by increased bone marrow activity. Hence, they implied a neurobiological pathway including the amygdala and bone marrow which connected the psychosocial stress to adiposity in humans.