Jing W, et al. - Researchers scrutinized the frequency of FRS2 amplification and its correlation with the clinicopathological features of atypical lipomatous tumour (ALT)/well-differentiated liposarcoma (WDL)/de-differentiated liposarcoma (DDL). A high percentage of homologous pleomorphic liposarcoma-like DDLs (two of three) were noted in the MDM2⁺/FRS2^- group. Data demonstrated that FRS2 was amplified consistently in ALT/WDL/DDLs and offer another avenue for the investigation of the biology of this tumour group. It was determined that MDM2⁺/FRS2^- cases were related to certain clinicopathological features.