Matthews CE, Moore SC, Arem H, et al. - Via assessing data from 9 prospective cohorts with self-reported leisure-time physical activity and follow-up for cancer incidence, researchers sought to assess if recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task hours/week) are correlated with lower cancer risk. Further, they drew the shape of the dose-response relationship, and examined relationships with moderate- and vigorous-intensity physical activity. They assessed data of a total of 755,459 participants (median age, 62 years [range, 32-91 years]; 53% female) with follow-up of 10.1 years; among these, 50,620 incident cancers accrued. They identified statistically significant lower risk of 7 of the 15 cancer types studied in correlation to engagement in recommended amounts of activity; lower risk was noted for colon cancer (8%-14% lower risk in men), breast cancer (6%-10% lower risk), endometrial cancer (10%-18% lower risk), kidney malignancy (11%-17% lower risk), myeloma (14%-19% lower risk), liver cancer (18%-27% lower risk), and non-Hodgkin lymphoma (11%-18% lower risk in women). In view of these findings, they suggest healthcare providers, fitness professionals, and public health practitioners to assist adults to adopt and maintain physical activity at recommended levels to lower risks of multiple cancers.