Kranke P, et al. - In this international, multicenter trial, researchers assessed the prophylactic efficacy of the dopamine D₂/D₃ antagonist amisulpride in combination with other antiemetics. Either intravenous amisulpride (5 mg) or matching placebo at induction of general anesthesia, in addition to one standard, nondopaminergic antiemetic, most commonly ondansetron or dexamethasone was received by adult surgical patients having three or four postoperative nausea and vomiting risk factors. Findings demonstrated that in adult patients at high risk for suffering postoperative nausea and vomiting undergoing elective surgery under inhalational general anesthesia, it was safe as well as efficacious to administer intravenous amisulpride as prophylaxis of postoperative nausea and vomiting when it was given in combination with an antiemetic from another class.