Amh highly correlates with cumulative live birth rate in women with diminished ovarian reserve independent of age
Journal of Clinical Endocrinology and Metabolism Mar 24, 2021
Tal R, Seifer DB, Tal R, et al. - Researchers conducted a retrospective analysis of Society for Assisted Reproductive Technology Clinic Outcome Reporting System database 2014-16 in order to determine how serum antimullerian hormone (AMH) correlate with cumulative live birth rates (CLBR) among women with diminished ovarian reserve (DOR) undergoing ART. A total of 34,540 index retrieval cycles of women with AMH < 1 ng/ml. Out of 133,442 autologous index retrieval cycles, they analyzed a total of 34,540 (25.9%) cycles with AMH < 1 ng/ml. Findings revealed a high correlation of serum AMH with CLBR in women with DOR independent of age. They indicated a strong correlation of serum AMH with number of oocytes retrieved, embryos cryopreserved, mean number of cumulative embryos transferred, and percentage of cycles that had an embryo transfer. More informative and personalized CLBR prediction could be made prior to ART via adding AMH to current age-based prognostication counseling particularly in women with DOR.
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