Xue C, et al. - Researchers assessed and compared the microstructural changes of the corpus callosum and its interhemispheric white matter fiber tracts interconnecting both cerebral hemispheres in subjects with adolescent idiopathic scoliosis and matched controls utilizing diffusion tensor imaging. For this analysis, brain DTI was performed in 69 subjects with adolescent idiopathic scoliosis and 40 age-matched controls without adolescent idiopathic scoliosis. They found reduced fractional anisotropy in the genu and splenium of the corpus callosum and corresponding interhemispheric fiber tracts interconnecting the somatosensory and visual cortices via the splenium. Findings suggestive of altered white matter microstructure within the brain of those with adolescent idiopathic scoliosis, which could be related to abnormal brain maturation during adolescence in adolescent idiopathic scoliosis and could possibly explain the previously documented somatosensory function impairment and visuo-oculomotor dysfunction in this condition.