Yuan J, et al. - The changes of local coherence and intrinsic brain activity were investigated in resting-state idiopathic trigeminal neuralgia (ITN) patients by using regional homogeneity (ReHo) and fractional aptitude of low-frequency fluctuation (fALFF) analysis. Researchers studied 23 ITN patients and 23 age-matched and sex-matched pain-free controls for the functional abnormality in the brains of ITN patients. ITN patients showed markedly abnormal spontaneous brain activity in several brain regions that are involved in pain modulation and perception in this work. The present study suggested the maladaptive process of daily pain attacks and might improve the understanding of how chronic pain affects local intrinsic brain activity.