Zhang D, Huang X, Su W, et al. - Researchers examined the structural and functional connectivity changes of lateral geniculate nucleus (LGN) in patients without aura. Further, they determined the relationships of these changes with clinical characteristics. Thirty migraine patients without aura (MwoA) and 22 healthy controls (HC) underwent conventional MRI, 3D structure images and resting state functional MRI. Mainly in the left cerebellum and right lingual gyrus, the brain regions with elevated functional connectivity (FC) of the left LGN were located in MwoA vs HC. The location of the increased FC of right LGN was in the left inferior frontal gyrus in MwoA vs HC. As per the correlation analysis, there was a positive correlation between the Visual Light Sensitivity Questionnaire-8 score and the enhanced FC of the left cerebellum and right lingual gyrus. Findings suggest a possible mediatory role of abnormal resting-state functional connectivity in visual processing regions, the pain perception regulatory network and emotion regulation network in photophobia in MwoA. This result has implication for enhancing the understanding concerning the clinical manifestation and pathogenesis of migraine.