Zhang XD, Zhao LR, Zhou JM, et al. - A resting-state fMRI study was performed to evaluate the changes in hippocampal functional connectivity (FC) in primary Sjögren syndrome (pSS) by using resting-state functional magnetic resonance imaging (rs-fMRI). A total of 38 individuals with pSS and 38 age- and education level-matched healthy controls (HCs) were included who underwent magnetic resonance imaging examination. Neuropsychological tests were conducted prior to each MRI examination. This study examined the left and right hippocampal FCs by using seed-based whole-brain correlation and compared between pSS and HCs. The study found that individuals with pSS suffered decreased hippocampal FC mainly sited in the occipital and temporal cortex with right hippocampal laterality. In pSS, altered hippocampal FC might be a potential biomarker in identifying brain function changes and guiding neuroprotection.