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Altered functional connectivity of the marginal division in Parkinson's disease with mild cognitive impairment: A pilot resting-state fMRI study

Journal of Magnetic Resonance Imaging Jun 21, 2019

Li MG, et al. - Through a prospective pilot study of 25 patients with Parkinson's disease mild cognitive impairment (PD-MCI); 25 PD patients and no cognitive impairment (PD-NCI); and 25 healthy control (HC) participants, the researchers intended to utilise resting-state functional magnetic resonance imaging (rs-fMRI) in order to explore the altered functional connectivity (FC) of the marginal division (MrD). A significant correlation between neuropsychological scores in patients with PD and the strength of FC between the MrD and regions that showed differences between the PD-MCI and PD-NCI groups was observed. Hence, it was concluded from the study that MrD dysfunction could contribute to MCI in PD. Although, the mechanisms underlying this process demands further investigation.
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