He T, Wang H, Sun J, et al. - Since benign thyroid nodules (BTN) are often diagnosed as papillary thyroid carcinoma (PTC), leading to unnecessary treatment, researchers studied the roles of DLG1-AS1 and miR-199a-3p in PTC and examined the clinical values of DLG1-AS1 for this disease. DLG1-AS1 and miR-199a-3p were detected by qPCR in the plasma of both patients with PTC and BTN. The sample consisted of 60 PTC individuals (age: 29 to 67 years; mean: 48.1 ± 5.5 years), 60 BTN individuals (age: 30 to 67 years; mean: 48.3 ± 5.9 years), and 60 healthy controls (age: 28 to 67 years; mean: 47.9 ± 5.0 years). By downregulating miR-199a-3p to promote cancer cell proliferation, DLG1-AS1 plays oncogenic roles in PTC. Furthermore, measuring plasma levels of DLG1-AS1 among the high-risk PTC population that improve early diagnosis.