Ince-Askan H, et al. - In this study, researchers examined if children born to mothers with rheumatoid arthritis (RA) differ from children born to mothers from the general population regarding the DNA methylation profile. Further, they examined how maternal RA disease activity or medication use during pregnancy influence the differences in methylation. Using the Infinium Illumina HumanMethylation 450K BeadChip, they measured genome-wide DNA methylation at cytosine-phosphate-guanine (CpG) sites in 80 blood samples from children (mean age=6.8 years) born to mothers with RA. From the population-based Generation R Study, blood samples from 354 children (mean age=6.0 years) were used as controls. Outcomes revealed differences in DNA methylation at 147 CpGs between children born to mothers with RA and children born to mothers from the general population. cg06642177, cg08867893, cg06778273, cg07786668 and cg20116574 were identified as the most significantly associated CpGs. No association of the differences in methylation with maternal RA disease activity or medication use during pregnancy was identified.