Zheng BX, Yin Y, Xiao H, et al. - This study was attempted to assess if individuals with phantom limb pain (PLP) and PLP‐free lower‐limb amputees exhibit changes in corresponding M1/S1 cortical reorganization and supplementary motor area (SMA) network functional connectivity (FC). Researchers also examined relationship between functional magnetic resonance imaging (fMRI) variations and clinical parameters.They matched a total of ten PLP patients with ten PLP‐free amputees and ten healthy controls (HCs). This study’s findings demonstrate that PLP in lower‐limb amputees is correlated with M1/S1 cortical reorganization and altered SMA network FC in different areas of the brain, which could help to support the understanding of the central mechanism of PLP.