Shin KJ, et al. - In this study performed on 35 patients with migraine without aura and 40 healthy controls, researchers focused on the changes of thalamic nuclei volumes and the intrinsic thalamic network in patients suffering from migraine. They performed three-dimensional T1-weighted imaging on all participants. They used the FreeSurfer program to segment thalamic nuclei. Among patients with migraine vs healthy controls, they found no difference in right and left thalamic volumes as a whole. However, patients with migraine vs healthy controls demonstrated significantly raised right anteroventral and right and left medial geniculate nuclei volumes and reduced right and left parafascicular nuclei volumes. The groups did not differ in terms of network measures of the intrinsic thalamic network. Overall, patients suffering from migraine exhibited significant changes of thalamic nuclei volumes than healthy controls. These data might add to the underlying pathogenesis of the migraine.