Mehta N, et al. - Since the implementation of a new national policy for alpha-fetoprotein (AFP) > 1,000 ng/mL requiring a reduction to < 500 ng/mL before liver transplantation (LT), researchers assessed the effects of a reduction in AFP from > 1,000 ng/mL to different AFP thresholds before LT on survival and hepatocellular carcinoma (HCC) recurrence after LT utilizing the United Network for Organ Sharing database. Between January 2005 and September 2015, 407 patients who underwent transplant and who had AFP > 1,000 ng/mL at least once before LT were identified. The data presented in this work showed significantly improved post-LT results when restricting LT to patients with a decrease in AFP from > 1,000 to < 500 ng/mL, validating the recently implemented national policy.