Huard M, Detrembleur C, Poilvache H, et al. - The present study was performed to analyze the alpha defensin qualitative detection (ADLF) sensitivity and specificity as compared with 3 standard classifications in the diagnostic management of chronic prosthetic joint infections. Researchers performed a multicenter cohort including a total of 136 individuals with a painful arthroplasty was divided into either infected or noninfected according to the Musculoskeletal Infection Society (MSIS) score, Infectious Diseases Society of America (IDSA) score, European Bone and Joint Infection Society (EBJIS) score. This study estimated the sensitivity and specificity of the ADLF test for each score. Spearman’s associations between all scores were then examined, and multiple logistic regression was used to distinguish independent variables strongly connected to the prosthetic joint infection probability. It was noted that the ADLF sensitivity was variable, whereas its specificity was excellent. The outcomes indicated that the EBJIS score appears significantly differed from those collected via cultures, which possibly explains the ADLF low sensitivity in comparison with that of the EBJIS score.