Hiremath S, Ruzicka M, Petrcich W, et al. - In this population-based, retrospective cohort study conducted in Ontario, Canada, researchers evaluated the risk of hypotension and related adverse events in correlation with alpha-blocker (AB) use vs other blood pressure (BP)-lowering drugs among women (aged ≥ 66 years). They used Cox proportional hazards to assess the link of AB use and hypotension and related events (syncope, fall, and fracture) vs other BP-lowering drugs matched via a high dimensional propensity score. Findings revealed a higher risk of hypotension and hypotension-related events in correlation with the treatment of hypertension with ABs vs other BP-lowering agents in women. Exercising caution was recommended while using ABs, even as add on therapy for hypertension.