Allergic FcεRI- and pseudo-allergic MRGPRX2-triggered mast cell activation routes are independent and inversely regulated by SCF
Allergy Sep 08, 2017
Magda Babina M, et al. - The purpose of this study was to analyze inter-individual variability in skin mast cell (MC) responses to FcεRI-triggering versus those evoked by MRGPRX2. It was revealed that SCF can have selective MC-dampening functions. Remarkably, the data imply that subjects highly reactive in one pathway are not automatically hyper-responsive in terms of the alternative route.
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