Blaha MJ, Cainzos-Achirica M, Dardari Z, et al. - Among participants (n = 66,363) from a multi-center, retrospective cohort study—the CAC Consortium (mean age 54 years, 33% women)—researchers examined the long-term links between zero, minimal coronary artery calcium (CAC) and cause-specific mortality, especially after accounting for competing risks with other causes of mortality. Asymptomatic people undergoing CAC scoring for clinical risk evaluation were included in the CAC Consortium. Among these individuals, they frequently detected the presence of CAC = 0, which was related to low rates of all-cause mortality at 12 years of follow-up. The emerging consensus suggesting CAC = 0 as a unique population carrying favorable all-cause prognosis and a likely candidate of more flexible treatment goals in primary prevention, was supported by the findings. Aggressive preventive interventions in young adults could be triggered in the presence of any CAC.