Mohammad N, et al. - Given the frequent characterization of inflammatory myofibroblastic tumor (IMT) by genetic fusion of ALK with a variety of partner genes, which results in the activated ALK signaling pathway that can be targeted with kinase inhibitors, researchers investigated the specificity of ALK immunohistochemistry for IMTs among uterine mesenchymal and mixed epithelial/mesenchymal tumors. On 14 molecularly confirmed uterine IMTs and 260 other uterine pure mesenchymal and mixed epithelial/mesenchymal tumors, they performed ALK immunohistochemistry. Outcomes suggest that in uterine mesenchymal tumors, ALK is a very specific diagnostic immunohistochemical marker for ALK fusion. They recommend providing a strong consideration to the diagnosis of IMT, if ALK positivity is observed, in the work-up of uterine mesenchymal tumors, particularly smooth muscle tumors showing myxoid stromal changes.