Airagnes G, Lemogne C, Meneton P, et al. - Researchers investigated the prospective associations of alcohol, tobacco, cannabis use, and their combination, with job loss—while taking into account age, sex, overall health status, and depressive symptoms— among a large population-based sample of men and women. They included 18,879 working participants between 2012 and 2016 from the French population-based CONSTANCES cohort. Among these participants, there appeared to be an independent association of alcohol, tobacco, and cannabis use with job loss at 1-year; the relationships were noted as dose-dependent relationships. On simultaneous introduction, significant associations remained for the three substances without any between-substance interactions. Associations remained significant across almost all stratifications and over a 3-year follow-up period, as well as after adjustment for all the sociodemographic and occupational factors.