Iskandar IYK, Lunt M, Thorneloe RJ, et al. - This prospective cohort study was undertaken to determine if alcohol abuse is correlated with poor response to treatment for psoriasis. To investigate factors associated with changes in Psoriasis Area and Severity Index between baseline and follow-up, a multivariable factional polynomial linear regression model was used. The sample consisted of 266 patients (biologic cohort, n = 134; conventional systemic cohort, n = 132). The poor response to therapy associated with alcohol abuse and obesity in psoriasis patients necessitates lifestyle behaviour change interventions and support as part of routine clinical care. Interventions aimed at preventing, detecting, and managing alcohol abuse in people with psoriasis are required to reduce negative health consequences and improve treatment response.