Anyanwagu U, et al. - Given that overt albuminuria (urinary albumin-creatinine ratio [ACR] > 300 mg/g) is an established risk factor for progression of nephropathy and total mortality, researchers investigated the influence of a reduction in ACR on all-cause mortality and cardiovascular (CV) events among insulin-treated patients with type 2 diabetes (T2D). Data of a total of 11,074 patients with insulin-treated T2D from UK general practices between 2007 and 2014 was analyzed. Outcomes suggest that in routine practice, patients with insulin-treated T2D and nephropathy display a significant reduction in all-cause mortality in correlation with a regression in albuminuria (eg, via better BP or glycemic control). Thereby suggesting albuminuria as a risk marker of renal and CV disease as well as an independent target for therapy.