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Albuminuria as a predictor of cardiovascular outcomes in patients with acute myocardial infarction

Journal of the American Heart Association Apr 11, 2019

Mok Y, et al. - Researchers investigated the effect of albuminuria on the prognosis of patients with myocardial infarction (MI). A total of 2,469 patients with incident MI were identified in the Stockholm Creatinine Measurements project (2006–2012); these subjects had dipstick proteinuria estimated within a year prior to MI (427 patients also had urine albumin to creatinine ratio [ACR] measured concurrently). The investigators recorded estimates for ACR with multiple imputation in participants with data solely on dipstick proteinuria. They assessed the relationship of ACR with the post-MI composite and individual outcomes of all-cause mortality, cardiovascular mortality, recurrent MI, ischemic stroke, or heart failure. Findings revealed an independent association of higher ACR levels with all outcomes except for ischemic stroke. Improvement in the C statistic of the post-MI composite by 0.040 was seen as a result of the addition of the ACR. Albuminuria was identified as a potent predictor of subsequent outcomes in MI patients. This suggests that, in this high-risk population, albuminuria also warrants attention in addition to kidney function.

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