Albuminuria and low bone mineral density in paediatric patients with type 1 diabetes
Journal of Paediatrics and Child Health Apr 17, 2019
de Souza KSC, et al. - In children and adolescents with type 1 diabetes (T1D), researchers assessed glycemic control and its impact on albuminuria and bone mineral density (BMD). For this investigation, they collectively evaluated 84 T1D children/adolescents (T1D group), aged 6 to 17 years, and then split them into T1D with good glycemic control (T1DG group) and T1D with poor glycemic control (T1DP group). They evaluated serum glucose, glycated hemoglobin, serum urea, serum creatinine, urinary albumin-to-creatinine ratio (ACR), estimated glomerular filtration rate and BMD levels. According to results, 77% of the patients studied had poor glycemic control. When compared to the T1DG group, patients with T1DP exhibited an increased ACR and a low BMD. Findings revealed that poor glycemic control in children and adolescents with T1D was linked with albuminuria, implying a negative effect on bone tissue and resulting in low BMD in these patients.
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