Liu X, Li Y, Zhao Q, et al. - By retrospectively examining 167 driver mutation‐negative advanced non‐small cell lung cancers (DANSCLCs) and 58 healthy controls, researchers assessed the clinical significance of albumin‐to‐alkaline phosphatase ratio (AAPR) in this patient population. A correlation of low AAPR level in DANSCLCs with poor differentiation was revealed in correlation analysis. For both PFS and OS, higher AUC were generated by AAPR vs that of ALB and ALP. Much shorter PFS and OS were observed in relation to low AAPR vs the high AAPR. Overall, findings revealed that patients with DANSCLC had significantly decreased AAPR and their prognosis was also impacted by AAPR. In this study, AAPR was acknowledged as a biomarker for DANSCLCs prognosis as well as treatment choice.