Madoff LU, et al. - Via this retrospective review of mucopolysaccharidoses (MPS) patients, researchers assessed the difficulty of airway management in these subjects over time as well as assessed how airway difficulty was influenced by bone marrow transplant and/or enzyme replacement therapy. A progression toward difficult intubation was noted with the aging of patients with MPS. With age, mask ventilation and laryngeal mask airway placement did not become more difficult. In these patients, airway difficulty was not influenced by bone marrow transplantation, while there was a link between enzyme replacement therapy and difficult intubations in younger patients.