Air pollution and IgE sensitization in four European birth cohorts - the MeDALL project
The Journal of Allergy and Clinical Immunology Sep 16, 2020
Melén E, Standl M, Gehring U, et al. - Since there exists controversy regarding whether long-term air pollution exposure has impacts on allergic sensitization, therefore, researchers examined links of air pollution exposure at birth as well as at the time of later biosampling, with immunoglobulin E sensitization against common food/inhalant allergens, or specific allergen molecules, in pediatric population up to 16 years. This meta-analysis involved up to 6,163 children from four European birth cohorts partaking in the MeDALL ( The Mechanisms of the Development of ALLergy) Consortium: BAMSE ( Children, Allergy, Milieu, Stockholm, Epidemiology)(Sweden), LISA (Influences of Lifestyle Related Factors on the Human Immune System and Development of Allergies in Childhood)/GINIplus (German Infant Study on the influence of Nutrition Intervention PLUS environmental and genetic influences on allergy development)(Germany), and PIAMA (Prevention and incidence of asthma and mite allergy) (The Netherlands). According to the findings, no increase in the overall risk of allergic sensitization appeared in relation to air pollution exposure, however, it was suggested that sensitization to birch as well as grass pollen Phl_p_1 and cat Fel_d_1 allergen molecules may be associated with specific pollutants.
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