Ibáñez–Costa A, et al. – Researchers conclude the most current studies on AIP–related pituitary adenomas, paying special attention to: the causes of the resistance to treatment in acromegaly; the somatostatin receptor profile in the somatotrophinoma, particularly type 2, and type 5 and its truncated variants; the role of G proteins in this pathology; the use of pasireotide, a novel multi–ligand somatostatin analogues; and the role of ZAC1, a zinc–finger protein which, among other functions, acts as a key mediator in octreotide response in somatotrophinoma models and, interestingly, its expression is linked to AIP.